Expression of P63 in Primary Cutaneous Adnexal Neoplasms and Adenocarcinoma Metastatic to the Skin
Identifieur interne : 008407 ( Main/Exploration ); précédent : 008406; suivant : 008408Expression of P63 in Primary Cutaneous Adnexal Neoplasms and Adenocarcinoma Metastatic to the Skin
Auteurs : Doina Ivan ; A. Hafeez Diwan ; Victor G. PrietoSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
p63, a recently identified homologue of p53 gene, has been reported to be essential in the development of epithelia and is mainly expressed by basal and myoepithelial cells. The purpose of this study was to investigate the pattern of p63 expression in cutaneous adnexal neoplasms and to assess its possible value in the differential diagnosis of primary cutaneous neoplasms versus adenocarcinomas metastatic to the skin. Immunohistochemical analysis using p63 monoclonal antibody (clone 4A4) was performed on formalin‐fixed, paraffin‐embedded archival tissue from 20 benign adnexal tumors, 10 malignant adnexal tumors, and 14 adenocarcinomas metastatic to the skin. The expression of p63 was evaluated in epidermal cells, skin appendages and metastatic tumor cells. p63 was consistently expressed in the basal/suprabasal cells of epidermis and cutaneous appendages, including the basal/myoepithelial cells of sweat glands. Thirteen out of 20 (65%) benign adnexal tumors showed strong p63 expression; the remaining 7(35%) cases had over 50% p63‐positive nuclei. All primary cutaneous carcinomas, including adenocarcinomas, expressed p63. In contrast, none of the metastatic adenocarcinomas to the skin was positive for p63 (p < 0.0001). Based on our findings, analysis of p63 expression may be a helpful tool in the differential diagnosis of primary versus metastatic cutaneous adenocarcinomas.
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DOI: 10.1111/j.0303-6987.2005.320cz.x
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Hafeez Diwan</name><affiliation><wicri:noCountry code="subField">Houston</wicri:noCountry></affiliation></author><author><name sortKey="Prieto, Victor G" sort="Prieto, Victor G" uniqKey="Prieto V" first="Victor G." last="Prieto">Victor G. Prieto</name><affiliation><wicri:noCountry code="subField">Houston</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="94">94</biblScope><biblScope unit="page" to="94">94</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">p63, a recently identified homologue of p53 gene, has been reported to be essential in the development of epithelia and is mainly expressed by basal and myoepithelial cells. The purpose of this study was to investigate the pattern of p63 expression in cutaneous adnexal neoplasms and to assess its possible value in the differential diagnosis of primary cutaneous neoplasms versus adenocarcinomas metastatic to the skin. Immunohistochemical analysis using p63 monoclonal antibody (clone 4A4) was performed on formalin‐fixed, paraffin‐embedded archival tissue from 20 benign adnexal tumors, 10 malignant adnexal tumors, and 14 adenocarcinomas metastatic to the skin. The expression of p63 was evaluated in epidermal cells, skin appendages and metastatic tumor cells. p63 was consistently expressed in the basal/suprabasal cells of epidermis and cutaneous appendages, including the basal/myoepithelial cells of sweat glands. Thirteen out of 20 (65%) benign adnexal tumors showed strong p63 expression; the remaining 7(35%) cases had over 50% p63‐positive nuclei. All primary cutaneous carcinomas, including adenocarcinomas, expressed p63. In contrast, none of the metastatic adenocarcinomas to the skin was positive for p63 (p < 0.0001). Based on our findings, analysis of p63 expression may be a helpful tool in the differential diagnosis of primary versus metastatic cutaneous adenocarcinomas.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hafeez Diwan, A" sort="Hafeez Diwan, A" uniqKey="Hafeez Diwan A" first="A." last="Hafeez Diwan">A. Hafeez Diwan</name><name sortKey="Ivan, Doina" sort="Ivan, Doina" uniqKey="Ivan D" first="Doina" last="Ivan">Doina Ivan</name><name sortKey="Prieto, Victor G" sort="Prieto, Victor G" uniqKey="Prieto V" first="Victor G." last="Prieto">Victor G. Prieto</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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